Flexible-Sustainable-and Leased Millennium Pharmaceuticals
"R&D's 2003, Lab of the Year"
Haiges, Shooshanian Engineering, Inc.
David P. Manfredi,
Our project case study is that of Millennium Pharmaceuticals'
35 Lansdowne Street project in Cambridge MA. This 220,000 square
foot pharmaceutical research facility just received the R&D
2003 "Lab of the Year Award." The building is owned by
Forest City Commercial Group yet leased by and built to suit for
Millennium. This seven-story facility is dedicated to drug discovery
in the areas of cardiovascular, oncology, inflammation and metabolics.
Additionally the facility includes specialty labs such as process
development radio synthesis, formulation labs and a vivarium.
The objective of our presentation is to convey:
1. The unique attributes of this laboratory are that it is developer
owned and built yet fully occupied by a single pharmaceutical client
on a built to suit basis, that the building is designed for maximum
flexibility yet with maximum chemistry densities, that the building
is located in a dense urban environment, is high-rise and built
to a high hazard code classification, that the building sits in
a University Park context in the heart of the Harvard/ MIT community,
and that the building must respond to an extremely competitive environment
both in attracting qualified researchers and demanding good science.
2. That successful projects must have committed players in order
to meet project objectives. All parties including the client, owner/developer,
designers and contractors must work as a team to bring the project
from a conceptual program to a commissioned, operating, functional
and efficient building.
3. That high-quality pharmaceutical laboratories can be sustainable.
Sustainable design begins as a project goal, not only with the owner's
commitment but also through the project delivery methods of the
entire team. Sustainable design is not a shortsighted objective
but rather a commitment to excellent environmental performance over
the life of the building.
Our presentation is a case study of a recently completed, commissioned
and occupied Pharmaceutical Research Facility. We will outline the
basic building metrics such as GSF, overall efficiency, lab/office
ratios, and costs for the base building shell and core as well as
fit out costs. The space program for both current occupancy and
extreme fit out loading will be identified.
For the engineering systems we will also identify the metrics of
the systems provided, their gross capacities as well as unit capacities.
A detailed overview of the sustainable design features will be provided.
From a "Labs 21" approach, this Millennium Pharmaceuticals
laboratory used an integrated "Whole Building" sustainable
approach in that the owner views this building for the long-term.
This single 220,000 square foot facility represents approximately
20 percent of Millennium's real estate in this urban location.
The design began with sensitivity to its contextual urban setting
and its dependence on public transportation. Building systems engineering
addressed building wide airside management in order to prohibit
unnecessary use of outside air. Engineering solutions included cascading
airstreams, VAV hood controls, manifold supply and exhaust systems,
modular and right sized equipment. Water efficiency was achieved
through process cooling loops and reuse of cooling tower water blow
down and other measures. Operational protocols were put in place
to assure that nasty materials are not put into the waste stream,
as well as safe guard measures of waste treatment in case of a spill.
Continuous monitoring of waste effluent is provided.
The facility incorporates enhanced control and monitoring systems
to assure continued efficiency as well as ongoing system diagnostics.
The facility was completely commissioned identifying proper operational
trends that will be used for future baseline reference and recommissioning.
Donald M. Haiges, PE,
a Principal of Shooshanian Engineering, Inc. in Boston, is a nationally
recognized leader in research and pharmaceutical facility design
and regularly lectures on these topics. Haiges received his degree
in Architectural Engineering from Pennsylvania State University
and has directed the mechanical and electrical engineering design
on many of today's leading research facilities. Shooshanian Engineering,
a 110-member firm, is ISO-9001 certified and specializes in technically
advanced building designs.
David P. Manfredi,
AIA is a founding partner of Elkus/Manfredi Architects, a 135 person
architectural design firm working in a diverse mix of building types.
Elkus/Manfredi has recently completed three biotech research facilities
at University Park at MIT.